Juma Amazon Lodge is located in a remote and untouched region 118 kilometers (73 miles) southeast of Manaus, in the municipality of Autazes. Situated on a peninsula surrounded by the Juma River, it has a fully preserved area of 7,000 hectares (17,300 acres). Juma can be reached in approximately 3 hours by van and boat in a very pleasant trip (the Meeting of the Waters of the Negro River and the Solimoes River is on the way to the lodge). The trip can also be made by hydroplane upon request and takes 30 minutes, landing right in front of the lodge.

The property has been built on stilts upon solid ground resting at treetop level. The lodge is entirely eco-friendly in design and construction. Both the construction and the architectural style of the lodge reflect the techniques employed by the indigenous people of the Amazon River when building their own homes.