The Game Drive in Lake Mburo passes a variety of landscape features including acacia woodland, wetlands, grassy hillsides, rock outcrops and seasonally flooded valley floors. Early morning and late afternoon are the best times to roam the park in search of wildlife.

On a game drive in this park, one is assured of spotting Zebra, Buffalo, Impala, Warthog and Waterbuck. Visitors can also enjoy night drives making this an ideal activity to spot nocturnal animals such as bushbabies, pottos and perhaps even a leopard.