The Museum of Cartagena de Indias, also known as the Museo Historico de Cartagena de Indias, is a notable cultural establishment in Cartagena de Indias, Colombia. It is situated within the Palacio de la Inquisición, an outstanding representation of 18th-century civil architecture in Cartagena. The museum highlights the city’s role in shaping Colombian nationality and the culture of the Greater Caribbean. It offers a range of exhibits that engage the public, encompassing both permanent and temporary displays. The museum provides a comprehensive insight into Cartagena’s colonial history and emphasizes the indigenous communities that inhabited the region prior to the arrival of the Spaniards.