Based on the banks of the Kafue River, deep within Kafue National Park, Musekese's landscape shifts between miombo woodlands and open plains, and waterways, creating a environment that support a wide range of wildlife. Elephant herds are frequently seen during the dry season, while plains game such as sable, hartebeest, zebra, and large numbers of puku are common across the grasslands. Birding is particularly rewarding, with hundreds of species recorded in the area. A permanent, water-fed lagoon—locally called a dambo—draws wildlife throughout the year. Canoe safaris offer a quiet way to explore river channels rich in birds and hippos. Game drives and walking safaris help visitors explore further. A visit to the Musekese Conservation NGO Research Centre provides insight into ongoing efforts to protect the area.